Social behavioral changes in MPTP-treated monkey model of Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Social behavioral changes in MPTP-treated monkey model of Parkinson's disease
Parkinsonian patients experience not only the physical discomfort of motor disorders but also the considerable psychological distress caused by cognitive deficits and behavioral disorders. These two factors can result in a disruption of social relationships during the symptomatic and even the presymptomatic motor states of the disease. However, it remains difficult, if not impossible, to evalua...
متن کاملceftriaxone decreases mptp-induced behavioral disturbances in animal model of parkinson’s disease
background and purpose: progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of parkinson’s disease (pd). recent studies have shown ceftriaxone, a β-lactam antibiotic, to be a neuroprotective in various neurodegenerative disorders. hence, the present study aimed to investigate the effect of ceftriaxone on behavioral disturbances of pd in an animal model. method...
متن کامل4-aminopyridine decreases mptp-induced behavioral disturbances in animal model of parkinson’s disease
background and purpose: progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of parkinson’s disease (pd). although potassium channels affect neural activity and death in this area, little research has investigated the effect of potassium channel blockers, such as 4-aminopyridine in the pretreatment of pd. methods: fifty-six healthy male wistar rats were selecte...
متن کاملQuantitative Behavioral Assessment Methods for the Analysis of Graft-Induced Motor and Cognitive Function in the MPTP-Treated Parkinsonian Monkey
Although the MPTP-treated monkey is the best available model of Parkinson's disease in terms of neuropathophysiology, the usefulness of the model for the functional analysis of neural grafts requires methods that can determine the severity and persistence of the symptoms. Wide variation in response to MPTP and reports of "spontaneous" recovery may warrant a variety of assessment methods to dete...
متن کاملSaccadic eye movement deficits in the MPTP monkey model of Parkinson's disease.
Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are seen in patients with idiopathic Parkinsonism. The MPTP model offers excellent po...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2015
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2015.00042